MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid

OBJECTIVES: Sporadic mutations in MeCP2 are a hallmark of Rett syndrome (RTT). Many RTT brain organoid models have exhibited pathogenic phenotypes such as decreased spine density and small size of soma with altered electrophysiological signals. However, previous models are mainly focused on the phen...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Hyowon, Yoon, Sae‐Bom, Park, Jung Eun, Lee, Jung In, Kim, Hyun Young, Nam, Hye Jin, Cho, Heeyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351674/
https://www.ncbi.nlm.nih.gov/pubmed/37302988
http://dx.doi.org/10.1002/acn3.51799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351674/
https://www.ncbi.nlm.nih.gov/pubmed/37302988
http://dx.doi.org/10.1002/acn3.51799

Ejemplares similares