Mouse nuclear RNAi-defective 2 promotes splicing of weak 5′ splice sites

Removal of introns during pre-mRNA splicing, which is central to gene expression, initiates by base pairing of U1 snRNA with a 5′ splice site (5′SS). In mammals, many introns contain weak 5′SSs that are not efficiently recognized by the canonical U1 snRNP, suggesting alternative mechanisms exist. He...

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Detalles Bibliográficos
Autores principales: Flemr, Matyas, Schwaiger, Michaela, Hess, Daniel, Iesmantavicius, Vytautas, Ahel, Josip, Tuck, Alex Charles, Mohn, Fabio, Bühler, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351895/
https://www.ncbi.nlm.nih.gov/pubmed/37137667
http://dx.doi.org/10.1261/rna.079465.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351895/
https://www.ncbi.nlm.nih.gov/pubmed/37137667
http://dx.doi.org/10.1261/rna.079465.122

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