Cargando…

OCE-205, a Selective V1a Partial Agonist, Reduces Portal Pressure in Rat Models of Portal Hypertension

PURPOSE: Management of decompensated cirrhosis may include the use of vasoconstrictors that can lead to serious adverse events. OCE-205 was designed as a highly selective V1a receptor partial agonist, intended to have a wider therapeutic window than full vasopressin agonists. METHODS: We aimed to ch...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bukofzer, Stan, Harris, Geoffrey, Song, Susan, Cable, Edward E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352125/ https://www.ncbi.nlm.nih.gov/pubmed/37469992 http://dx.doi.org/10.2147/JEP.S416673

Ejemplares similares

OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis
por: Bukofzer, Stan, et al.
Publicado: (2023)

OCE-205, A Novel, Selective Vasopressin Receptor Mixed Agonist-Antagonist: Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics from a Phase 1 Study in Healthy Volunteers
por: Bagger, Yu, et al.
Publicado: (2023)

The Impact of Partial Splenic Embolization on Portal Hypertensive Gastropathy in Cirrhotic Patients with Portal Hypertension
por: Saeki, Michio, et al.
Publicado: (2023)

Endoscopic ultrasound-guided portal pressure gradient measurement in managing portal hypertension
por: Lesmana, Cosmas Rinaldi Adithya
Publicado: (2023)

Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension
por: Yao, Hongjuan, et al.
Publicado: (2020)

Portal Hypertension
por: Sun, Mingyu, et al.
Publicado: (2018)

Portale Hypertension
por: Bauer, J., et al.
Publicado: (2011)

Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension
por: Garcia‐Tsao, Guadalupe, et al.
Publicado: (2018)

Constriction rate variation produced by partial ligation of the portal vein at pre-hepatic portal hypertension induced in rats
por: RODRIGUES, Daren Athiê Boy, et al.
Publicado: (2014)

Hematological Indices in Portal Hypertension: Cirrhosis versus Noncirrhotic Portal Hypertension
por: Sahin, Abdurrahman, et al.
Publicado: (2018)

The circulation in portal hypertension.
por: Witte, C. L., et al.
Publicado: (1975)

Sinistral portal hypertension
por: Thompson, Richard J, et al.
Publicado: (2006)

Biology of portal hypertension
por: McConnell, Matthew, et al.
Publicado: (2017)

Pathophysiology of Portal Hypertension
por: Morales-Ruiz, Manuel, et al.
Publicado: (2015)

Mechanobiology of portal hypertension
por: Felli, Eric, et al.
Publicado: (2023)

AN EXPERIMENTAL STUDY INTO THE CAUSE OF THE INCREASED PORTAL PRESSURE IN PORTAL CIRRHOSIS
por: Herrick, Frederick C.
Publicado: (1907)

Intentional Modulation of Portal Venous Pressure by Splenectomy Saves the Patient with Liver Failure and Portal Hypertension After Major Hepatectomy: Is Delayed Splenectomy an Acceptable Therapeutic Option for Secondary Portal Hypertension?
por: Takamatsu, Yuichi, et al.
Publicado: (2018)

Dual Angiotensin Receptor and Neprilysin Inhibitor Ameliorates Portal Hypertension in Portal Hypertensive Rats
por: Hsu, Shao-Jung, et al.
Publicado: (2020)

Wall shear stress in portal vein of cirrhotic patients with portal hypertension
por: Wei, Wei, et al.
Publicado: (2017)

Extrahepatic Portal Vein Thrombosis, an Important Cause of Portal Hypertension in Children
por: Grama, Alina, et al.
Publicado: (2021)

Propranolol Reduces Portal Vein Diameter in Schistosomal Liver Disease with Portal Hypertension: A Prospective Cohort Study
por: Sinkala, Edford, et al.
Publicado: (2020)

Technique innovation of endoscopic ultrasound portal pressure gradient measurement using standard manometer set for portal hypertension assessment
por: Lesmana, Cosmas Rinaldi Adithya
Publicado: (2022)

Portal hypertension: pathophysiology and treatment

Erosive Gastritis and Portal Hypertension
por: Geraghty, J. G., et al.
Publicado: (1992)

Management of Portal Hypertension in Children
por: Mileti, Elizabeth, et al.
Publicado: (2010)

Carvedilol in the Treatment of Portal Hypertension
por: Al-Ghamdi, Hamdan
Publicado: (2011)

The kidney in cirrhosis with portal hypertension
por: Olteanu, D, et al.
Publicado: (2010)

Clinical Manifestations of Portal Hypertension
por: Al-Busafi, Said A., et al.
Publicado: (2012)

Endoscopic Management of Portal Hypertension
por: Al-Busafi, Said A., et al.
Publicado: (2012)

On Certain Aspects of Portal Hypertension
por: Learmonth, James
Publicado: (1951)

Management of Complications of Portal Hypertension
por: Vilela, Eduardo Garcia, et al.
Publicado: (2019)

An Anomalous Cause of Portal Hypertension
por: Brown, Sara A., et al.
Publicado: (2021)

Assessment of intrahepatic blood flow by Doppler ultrasonography: Relationship between the hepatic vein, portal vein, hepatic artery and portal pressure measured intraoperatively in patients with portal hypertension
por: Zhang, Li, et al.
Publicado: (2011)

Gender differences in vascular reactivity of mesenteric arterioles in portal hypertensive and non-portal hypertensive rats
por: Zhang, Bin, et al.
Publicado: (2019)

A Narrative Review on Non-Cirrohotic Portal Hypertension: Not All Portal Hypertensions Mean Cirrhosis
por: Fiordaliso, Michele, et al.
Publicado: (2023)

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats
por: Gunarathne, Lakmie S., et al.
Publicado: (2019)

The role of nitric oxide in portal hypertension caused by extrahepatic portal vein obstruction
por: Goel, P., et al.
Publicado: (2010)

The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model
por: Schwabl, Philipp, et al.
Publicado: (2021)

Maximizing Regulatory Review Efficiency: The Evolution of the FDA OCE RTOR Pilot
por: Gao, Ya Grace, et al.
Publicado: (2022)

The incidence of portal hypertension in children with choledochal cyst and the correlation of nitric oxide levels in the peripheral blood with portal pressure and liver histology
por: Chand, Karunesh, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ukqivloqvf6oqtc530nu30sg5g