Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism

The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is cleared from the synaptic cleft by the sodium- and chloride-coupled GABA transporter GAT1. Inhibition of GAT1 prolongs the GABAergic signaling at the synapse and is a strategy to treat certain forms of epilepsy. In this study, we present...

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Detalles Bibliográficos
Autores principales: Nayak, Smruti Ranjan, Joseph, Deepthi, Höfner, Georg, Dakua, Archishman, Athreya, Arunabh, Wanner, Klaus T., Kanner, Baruch I., Penmatsa, Aravind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352132/
https://www.ncbi.nlm.nih.gov/pubmed/37400654
http://dx.doi.org/10.1038/s41594-023-01011-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352132/
https://www.ncbi.nlm.nih.gov/pubmed/37400654
http://dx.doi.org/10.1038/s41594-023-01011-w

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