P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium

Impaired autophagy promotes Inflammatory Bowel Disease (IBD). Claudin-2 is upregulated in IBD however its role in the pathobiology remains uncertain due to its complex regulation, including by autophagy. Irrespective, claudin-2 expression protects mice from DSS colitis. This study was undertaken to...

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Detalles Bibliográficos
Autores principales: Ahmad, Rizwan, Kumar, Balawant, Tamang, Raju Lama, Talmon, Geoffrey A., Dhawan, Punita, Singh, Amar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352296/
https://www.ncbi.nlm.nih.gov/pubmed/37460613
http://dx.doi.org/10.1038/s42003-023-05116-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352296/
https://www.ncbi.nlm.nih.gov/pubmed/37460613
http://dx.doi.org/10.1038/s42003-023-05116-2

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