Cargando…

AraC interacts with p75(NTR) transmembrane domain to induce cell death of mature neurons

Cytosine arabinoside (AraC) is one of the main therapeutic treatments for several types of cancer, including acute myeloid leukaemia. However, after a high-dose AraC chemotherapy regime, patients develop severe neurotoxicity and cell death in the central nervous system leading to cerebellar ataxia,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lopes-Rodrigues, Vanessa, Boxy, Pia, Sim, Eunice, Park, Dong Ik, Habeck, Michael, Carbonell, Josep, Andersson, Annika, Fernández-Suárez, Diana, Nissen, Poul, Nykjær, Anders, Kisiswa, Lilian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352303/ https://www.ncbi.nlm.nih.gov/pubmed/37460457 http://dx.doi.org/10.1038/s41419-023-05979-7

Ejemplares similares

Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development
por: Boxy, Pia, et al.
Publicado: (2023)

DNA tape measurements of AraC
por: Rodgers, Michael E., et al.
Publicado: (2008)

MAG induces apoptosis in cerebellar granule neurons through p75(NTR) demarcating granule layer/white matter boundary
por: Fernández-Suárez, Diana, et al.
Publicado: (2019)

Correction: MAG induces apoptosis in cerebellar granule neurons through p75(NTR) demarcating granule layer/white matter boundary
por: Fernández-Suárez, Diana, et al.
Publicado: (2019)

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis
por: Evangelopoulos, Dimitrios, et al.
Publicado: (2014)

AraC-Based Biosensor for the Detection of Isoprene in E. coli
por: Bhat, Shrilaxmi, et al.
Publicado: (2023)

Liposomally trapped AraCTP to overcome AraC resistance in a murine lymphoma in vitro.
por: Richardson, V. J., et al.
Publicado: (1982)

FoxR is an AraC‐like transcriptional regulator of ferrioxamine uptake in Salmonella enterica
por: Saldaña‐Ahuactzi, Zeus, et al.
Publicado: (2022)

A large family of anti‐activators accompanying XylS/AraC family regulatory proteins
por: Santiago, Araceli E., et al.
Publicado: (2016)

A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT
por: Woodbrey, Anne K., et al.
Publicado: (2017)

The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria
por: Santiago, Araceli E., et al.
Publicado: (2017)

Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator
por: Shi, Jing, et al.
Publicado: (2022)

Signal amplification of araC pBAD using a standardized translation initiation region
por: Shilling, Patrick J, et al.
Publicado: (2022)

Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity
por: Cha, Ming C, et al.
Publicado: (2005)

Blockade of CD82 by a monoclonal antibody potentiates anti-leukemia effects of AraC in vivo
por: Nishioka, Chie, et al.
Publicado: (2015)

Characterization of a novel AraC/XylS-regulated family of N-acyltransferases in pathogens of the order Enterobacterales
por: Belmont-Monroy, Laura, et al.
Publicado: (2020)

Computer-Based Annotation of Putative AraC/XylS-Family Transcription Factors of Known Structure but Unknown Function
por: Schüller, Andreas, et al.
Publicado: (2012)

1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae
por: Li, Jiaqin, et al.
Publicado: (2016)

A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae
por: Lee, Hye-Young, et al.
Publicado: (2022)

The AraC-Type Transcriptional Regulator GliR (PA3027) Activates Genes of Glycerolipid Metabolism in Pseudomonas aeruginosa
por: Kotecka, Karolina, et al.
Publicado: (2021)

Unveiling a Virulence-Regulating Mechanism in Aeromonas hydrophila: a Quantitative Exoproteomic Analysis of an AraC-Like Protein
por: Zhang, Lishan, et al.
Publicado: (2023)

Development of a new fluorescent reporter:operator system: location of AraC regulated genes in Escherichia coli K-12
por: Sellars, Laura E., et al.
Publicado: (2017)

Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric Pathogens
por: Bosire, Erick Maosa, et al.
Publicado: (2020)

Age‐related changes in hippocampal‐dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor
por: Wong, Lik‐Wei, et al.
Publicado: (2021)

The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells
por: Zhao, Manzhu, et al.
Publicado: (2020)

An improved Escherichia coli strain to host gene regulatory networks involving both the AraC and LacI inducible transcription factors
por: Kogenaru, Manjunatha, et al.
Publicado: (2014)

SAV742, a Novel AraC-Family Regulator from Streptomyces avermitilis, Controls Avermectin Biosynthesis, Cell Growth and Development
por: Sun, Di, et al.
Publicado: (2016)

OnfD, an AraC-Type Transcriptional Regulator Encoded by Rhizobium tropici CIAT 899 and Involved in Nod Factor Synthesis and Symbiosis
por: del Cerro, Pablo, et al.
Publicado: (2020)

4-Chlorophenol Oxidation Depends on the Activation of an AraC-Type Transcriptional Regulator, CphR, in Rhodococcus sp. Strain YH-5B
por: Zhang, Hui, et al.
Publicado: (2018)

Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis
por: Li, Linzhang, et al.
Publicado: (2022)

R-CHOP intensification with mid-cycle methotrexate and consolidating AraC/TT with BCNU/aHSCT in primary aggressive lymphoma with CNS involvement
por: Steinhardt, Maximilian J., et al.
Publicado: (2021)

Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2’-deoxyuridine (FUdR)
por: Lesslich, Heiko M., et al.
Publicado: (2022)

p75(NTR) in Huntington's disease: beyond the basal ganglia
por: Brito, Verónica, et al.
Publicado: (2015)

Retracted: Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis
por: Healthcare Engineering, Journal of
Publicado: (2023)

Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains
por: Zhang, Ning, et al.
Publicado: (2021)

Structural Characterization of the Self-Association of the Death Domain of p75(NTR)
por: Qu, Qianhui, et al.
Publicado: (2013)

Overexpression of p75(NTR) in Human Seminoma: A New Biomarker?
por: Perri, Anna, et al.
Publicado: (2021)

Correction: Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains
por: Zhang, Ning, et al.
Publicado: (2022)

BfvR, an AraC-Family Regulator, Controls Biofilm Formation and pH6 Antigen Production in Opposite Ways in Yersinia pestis Biovar Microtus
por: Fang, Haihong, et al.
Publicado: (2018)

AraC-induced neuron-like differentiation of human NTERA2/D1 cells and quantification of endogenous pre-mir-106b and 19b levels
por: Kaneko, Yuka, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_53vuehtaneevajfpecmo7m5ah0