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Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex‐specific pattern

Decline in neuromuscular function with aging is known to be a major determinant of disability and all‐cause mortality in late life. Despite the importance of the problem, the neurobiology of age‐associated muscle weakness is poorly understood. In a previous report, we performed untargeted metabolomi...

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Detalles Bibliográficos
Autores principales: Chung, Tae, Bopp, Taylor, Ward, Chris, Notarangelo, Francesca M., Schwarcz, Robert, Westbrook, Reyhan, Xue, Qian‐Li, Walston, Jeremy, Hoke, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352574/
https://www.ncbi.nlm.nih.gov/pubmed/37078472
http://dx.doi.org/10.1111/acel.13849