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Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays
During gene therapy trials, immune responses against adeno-associated virus (AAV) vectors are monitored by antibody assays that detect the humoral and T-cell mediated cellular responses to AAV vectors. T cell assays commonly utilize the collection of patients’ peripheral blood mononuclear cells (PBM...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352612/ https://www.ncbi.nlm.nih.gov/pubmed/37469509 http://dx.doi.org/10.3389/fimmu.2023.1211529 |