Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model

Post-traumatic epilepsy (PTE) occurs in some patients after moderate/severe traumatic brain injury (TBI). Although there are no approved therapies to prevent epileptogenesis, levetiracetam (LEV) is commonly given for seizure prophylaxis due to its good safety profile. This led us to study LEV as par...

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Detalles Bibliográficos
Autores principales: Coles, Lisa D., Saletti, Patricia G., Lisgaras, Christos Panagiotis, Casillas-Espinosa, Pablo M., Liu, Wei, Li, Qianyun, Jones, Nigel C., Shultz, Sandy, Ali, Idrish, Brady, Rhys, Yamakawa, Glenn, Hudson, Matt, Silva, Juliana, Braine, Emma, Mishra, Usha, Cloyd, James C., O’Brien, Terence J., Moshé, Solomon L., Galanopoulou, Aristea S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:
Neuropharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353071/
https://www.ncbi.nlm.nih.gov/pubmed/37316328
http://dx.doi.org/10.1124/jpet.122.001377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353071/
https://www.ncbi.nlm.nih.gov/pubmed/37316328
http://dx.doi.org/10.1124/jpet.122.001377

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