Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase

HIV-1 integrase-LEDGF allosteric inhibitors (INLAIs) share the binding site on the viral protein with the host factor LEDGF/p75. These small molecules act as molecular glues promoting hyper-multimerization of HIV-1 IN protein to severely perturb maturation of viral particles. Herein, we describe a n...

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Detalles Bibliográficos
Autores principales: Bonnard, Damien, Le Rouzic, Erwann, Singer, Matthew R., Yu, Zhe, Le Strat, Frédéric, Batisse, Claire, Batisse, Julien, Amadori, Céline, Chasset, Sophie, Pye, Valerie E., Emiliani, Stéphane, Ledoussal, Benoit, Ruff, Marc, Moreau, François, Cherepanov, Peter, Benarous, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353390/
https://www.ncbi.nlm.nih.gov/pubmed/37310224
http://dx.doi.org/10.1128/aac.00462-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353390/
https://www.ncbi.nlm.nih.gov/pubmed/37310224
http://dx.doi.org/10.1128/aac.00462-23

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