Bedquiline Resistance Mutations: Correlations with Drug Exposures and Impact on the Proteome in M. tuberculosis

Bedaquiline (BDQ) is an effective drug for the treatment of drug-resistant tuberculosis. Mutations in atpE, which encodes the target of BDQ, are associated with large increases in MICs. Mutations in Rv0678 that derepress the transcription of the MmpL5-MmpS5 efflux transporter are associated with sma...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Li, Dongshuo, Shi, Jinghua, Wang, Bin, Ge, Fei, Guo, Zhenyong, Mu, Xiaopan, Nuermberger, Eric, Lu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353445/
https://www.ncbi.nlm.nih.gov/pubmed/37255473
http://dx.doi.org/10.1128/aac.01532-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353445/
https://www.ncbi.nlm.nih.gov/pubmed/37255473
http://dx.doi.org/10.1128/aac.01532-22

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