CRISPRa‐based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning

BACKGROUND: Skeletal muscle‐secreted myokines widely participate in lipids metabolism through autocrine, paracrine and endocrine actions. The myokines represented by FGF21 and Irisin can promote the browning of adipocytes and serve as promising targets for treating obesity. Although recombinant myok...

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Detalles Bibliográficos
Autores principales: Zhu, Hongtao, Liu, Dan, Sui, Ming, Zhou, Meiling, Wang, Beibei, Qi, Qinqin, Wang, Ting, Zhang, Guo, Wan, Feng, Zhang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353577/
https://www.ncbi.nlm.nih.gov/pubmed/37462619
http://dx.doi.org/10.1002/ctm2.1326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353577/
https://www.ncbi.nlm.nih.gov/pubmed/37462619
http://dx.doi.org/10.1002/ctm2.1326

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