Cargando…
Human microglia show unique transcriptional changes in Alzheimer’s disease
Microglia, the innate immune cells of the brain, influence Alzheimer’s disease (AD) progression and are potential therapeutic targets. However, microglia exhibit diverse functions, the regulation of which is not fully understood, complicating therapeutics development. To better define the transcript...
Autores principales: | Prater, Katherine E., Green, Kevin J., Mamde, Sainath, Sun, Wei, Cochoit, Alexandra, Smith, Carole L., Chiou, Kenneth L., Heath, Laura, Rose, Shannon E., Wiley, Jesse, Keene, C. Dirk, Kwon, Ronald Y., Snyder-Mackler, Noah, Blue, Elizabeth E., Logsdon, Benjamin, Young, Jessica E., Shojaie, Ali, Garden, Gwenn A., Jayadev, Suman |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353942/ https://www.ncbi.nlm.nih.gov/pubmed/37248328 http://dx.doi.org/10.1038/s43587-023-00424-y |
Ejemplares similares
-
Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures
por: Aloi, Macarena S., et al.
Publicado: (2023) -
Early-Onset Familial Alzheimer Disease Variant PSEN2 N141I Heterozygosity is Associated with Altered Microglia Phenotype
por: Fung, Susan, et al.
Publicado: (2020) -
Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release
por: Jayadev, Suman, et al.
Publicado: (2010) -
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
por: Fixsen, Bethany R., et al.
Publicado: (2023) -
The spatiotemporal dynamics of microglia across the human lifespan
por: Menassa, David A., et al.
Publicado: (2022)