Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging

Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but underlying mechanisms are not understood. Analyses of 700 human blood transcriptomes revealed clear signs of age-associated low-grade inflammation. Among changes in mitochondrial components, we found that the exp...

Descripción completa

Detalles Bibliográficos
Autores principales: Seegren, Philip V., Harper, Logan R., Downs, Taylor K., Zhao, Xiao-Yu, Viswanathan, Shivapriya B., Stremska, Marta E., Olson, Rachel J., Kennedy, Joel, Ewald, Sarah E., Kumar, Pankaj, Desai, Bimal N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353943/
https://www.ncbi.nlm.nih.gov/pubmed/37277641
http://dx.doi.org/10.1038/s43587-023-00436-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353943/
https://www.ncbi.nlm.nih.gov/pubmed/37277641
http://dx.doi.org/10.1038/s43587-023-00436-8

Ejemplares similares