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Chromatin accessibility dynamics of neurogenic niche cells reveal defects in neural stem cell adhesion and migration during aging
The regenerative potential of brain stem cell niches deteriorates during aging. Yet the mechanisms underlying this decline are largely unknown. Here we characterize genome-wide chromatin accessibility of neurogenic niche cells in vivo during aging. Interestingly, chromatin accessibility at adhesion...
Autores principales: | Yeo, Robin W., Zhou, Olivia Y., Zhong, Brian L., Sun, Eric D., Navarro Negredo, Paloma, Nair, Surag, Sharmin, Mahfuza, Ruetz, Tyson J., Wilson, Mikaela, Kundaje, Anshul, Dunn, Alexander R., Brunet, Anne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353944/ https://www.ncbi.nlm.nih.gov/pubmed/37443352 http://dx.doi.org/10.1038/s43587-023-00449-3 |
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