High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

Reoccurring/high-risk neuroblastoma (NB) tumors have the enrichment of non-RAS/RAF mutations along the mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that activation of MEK/ERK is critical for their survival. However, based on preclinical data, MEK inhibitors are unlikely to b...

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書目詳細資料
Autores principales: Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Dalton, Krista M., Coon, Colin, Greninger, Patricia, Egan, Regina K., Stein, Giovanna T., Murchie, Ellen, McClanaghan, Joseph, Adachi, Yuta, Hirade, Kentaro, Dozmorov, Mikhail, Glod, John, Boikos, Sosipatros A., Ebi, Hiromichi, Hao, Huaixiang, Caponigro, Giordano, Benes, Cyril H., Faber, Anthony C.
格式: Online Artículo Texto
語言:English
出版: 2022
主題:
Article
在線閱讀:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353975/
https://www.ncbi.nlm.nih.gov/pubmed/35905710
http://dx.doi.org/10.1016/j.celrep.2022.111095

因特網

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353975/
https://www.ncbi.nlm.nih.gov/pubmed/35905710
http://dx.doi.org/10.1016/j.celrep.2022.111095

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