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Chronically dysregulated corticosterone impairs dopaminergic transmission in the dorsomedial striatum by sex-divergent mechanisms

Major depressive disorder (MDD) is a leading cause of disability worldwide. Individuals with MDD exhibit decreased motivation and deficits in reward processing. In a subset of MDD patients, chronic dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis occurs, resulting in increased levels o...

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Detalles Bibliográficos
Autores principales: Holloway, Ashley L., Schaid, Michael D., Lerner, Talia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353992/
https://www.ncbi.nlm.nih.gov/pubmed/36810463
http://dx.doi.org/10.1038/s41386-023-01551-1