Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53 triggers transcription-independent apoptosis through direct interactions with BCL-2 family proteins, but the molecular mechanism is not well unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Hudie, Wang, Haolan, Wang, Genxin, Qu, Lingzhi, Jiang, Longying, Dai, Shuyan, Chen, Xiaojuan, Zhang, Ye, Chen, Zhuchu, Li, Youjun, Guo, Ming, Chen, Yongheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353994/
https://www.ncbi.nlm.nih.gov/pubmed/37463921
http://dx.doi.org/10.1038/s41467-023-40087-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353994/
https://www.ncbi.nlm.nih.gov/pubmed/37463921
http://dx.doi.org/10.1038/s41467-023-40087-2

Ejemplares similares