Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

Androgen deprivation therapy is given to suppress prostate cancer growth; however, some cells continue to grow hormone-independently as castration-resistant prostate cancer (CRPC). Sulfated glycosaminoglycans promote ligand binding to receptors as co-receptors, but their role in CRPC remains unknown...

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Detalles Bibliográficos
Autores principales: Ota, Hayato, Sato, Hirokazu, Mizumoto, Shuji, Wakai, Ken, Yoneda, Kei, Yamamoto, Kazuo, Nakanishi, Hayao, Ikeda, Jun-Ichiro, Sakamoto, Shinichi, Ichikawa, Tomohiko, Yamada, Shuhei, Takahashi, Satoru, Ikehara, Yuzuru, Nishihara, Shoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354070/
https://www.ncbi.nlm.nih.gov/pubmed/37463954
http://dx.doi.org/10.1038/s41598-023-38746-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354070/
https://www.ncbi.nlm.nih.gov/pubmed/37463954
http://dx.doi.org/10.1038/s41598-023-38746-x

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