Conformational restriction shapes the inhibition of a multidrug efflux adaptor protein

Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite multidrug efflux pump system from Escherichia coli, AcrAB-TolC, is a target for inhibition to lessen resistance development and restore antibiotic efficacy, with homologs in other ESKAPE pathogens. Here, we rat...

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Detalles Bibliográficos
Autores principales: Russell Lewis, Benjamin, Uddin, Muhammad R., Moniruzzaman, Mohammad, Kuo, Katie M., Higgins, Anna J., Shah, Laila M. N., Sobott, Frank, Parks, Jerry M., Hammerschmid, Dietmar, Gumbart, James C., Zgurskaya, Helen I., Reading, Eamonn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354078/
https://www.ncbi.nlm.nih.gov/pubmed/37463890
http://dx.doi.org/10.1038/s41467-023-39615-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354078/
https://www.ncbi.nlm.nih.gov/pubmed/37463890
http://dx.doi.org/10.1038/s41467-023-39615-x

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