JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT signaling pathway appears to be straightforward. However, on closer examination, the factors influencing the JAK/STAT s...

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Detalles Bibliográficos
Autores principales: Ott, Nils, Faletti, Laura, Heeg, Maximilian, Andreani, Virginia, Grimbacher, Bodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354173/
https://www.ncbi.nlm.nih.gov/pubmed/37140667
http://dx.doi.org/10.1007/s10875-023-01483-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354173/
https://www.ncbi.nlm.nih.gov/pubmed/37140667
http://dx.doi.org/10.1007/s10875-023-01483-x

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