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Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord

Unmyelinated non-peptidergic nociceptors (NP afferents) arborise in lamina II of the spinal cord and receive GABAergic axoaxonic synapses, which mediate presynaptic inhibition. However, until now the source of this axoaxonic synaptic input was not known. Here we provide evidence that it originates f...

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Detalles Bibliográficos
Autores principales: Davis, Olivia C., Dickie, Allen C., Mustapa, Marami B., Boyle, Kieran A., Browne, Tyler J., Gradwell, Mark A., Smith, Kelly M., Polgár, Erika, Bell, Andrew M., Kókai, Éva, Watanabe, Masahiko, Wildner, Hendrik, Zeilhofer, Hanns Ulrich, Ginty, David D., Callister, Robert J., Graham, Brett A., Todd, Andrew J., Hughes, David I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354228/
https://www.ncbi.nlm.nih.gov/pubmed/37464016
http://dx.doi.org/10.1038/s41598-023-38605-9