An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage

Pancreatic ductal adenocarcinoma (PDAC) is a highly treatment-resistant cancer. Currently, the only curative treatment for PDAC is surgery, but most patients are diagnosed with metastatic disease and thus outside the scope of surgery. The majority of metastatic patients receive chemotherapy, but res...

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Detalles Bibliográficos
Autores principales: Pakola, Santeri, Quixabeira, Dafne C. A., Kudling, Tatiana V., Clubb, James H. A., Grönberg-Vähä-Koskela, Susanna, Basnet, Saru, Jirovec, Elise, Arias, Victor, Haybout, Lyna, Heiniö, Camilla, Santos, Joao M., Cervera-Carrascon, Victor, Havunen, Riikka, Anttila, Marjukka, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354511/
https://www.ncbi.nlm.nih.gov/pubmed/37475863
http://dx.doi.org/10.3389/fimmu.2023.1171083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354511/
https://www.ncbi.nlm.nih.gov/pubmed/37475863
http://dx.doi.org/10.3389/fimmu.2023.1171083

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