Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols

We report the first example of a synthetic thiol-based compound that promotes oxidative protein folding upon 1-equivalent loading to the disulfide bonds in the client protein to afford the native form in over 70% yield. N-Methylation is a central post-translational processing of proteins in vivo for...

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Detalles Bibliográficos
Autores principales: Okada, Shunsuke, Matsumoto, Yosuke, Takahashi, Rikana, Arai, Kenta, Kanemura, Shingo, Okumura, Masaki, Muraoka, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355094/
https://www.ncbi.nlm.nih.gov/pubmed/37476727
http://dx.doi.org/10.1039/d3sc01540h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355094/
https://www.ncbi.nlm.nih.gov/pubmed/37476727
http://dx.doi.org/10.1039/d3sc01540h

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