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Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols
We report the first example of a synthetic thiol-based compound that promotes oxidative protein folding upon 1-equivalent loading to the disulfide bonds in the client protein to afford the native form in over 70% yield. N-Methylation is a central post-translational processing of proteins in vivo for...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355094/ https://www.ncbi.nlm.nih.gov/pubmed/37476727 http://dx.doi.org/10.1039/d3sc01540h |