Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways

Notch3 (neurogenic locus notch homolog protein 3) is implicated in vascular diseases, including pulmonary hypertension (PH)/pulmonary arterial hypertension. However, molecular mechanisms remain elusive. We hypothesized increased Notch3 activation induces oxidative and endoplasmic reticulum (ER) stre...

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Detalles Bibliográficos
Autores principales: Morris, Hannah E., Neves, Karla B., Nilsen, Margaret, Montezano, Augusto C., MacLean, Margaret R., Touyz, Rhian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355806/
https://www.ncbi.nlm.nih.gov/pubmed/37254738
http://dx.doi.org/10.1161/HYPERTENSIONAHA.122.20449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355806/
https://www.ncbi.nlm.nih.gov/pubmed/37254738
http://dx.doi.org/10.1161/HYPERTENSIONAHA.122.20449

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