More than bad luck: Cancer and aging are linked to replication-driven changes to the epigenome

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation of somatic mutations drives this relationship, it is likely not the full story. We show that aging and cancer share a common epigenetic replication signature, which we modeled using DNA methylation from ext...

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Detalles Bibliográficos
Autores principales: Minteer, Christopher J., Thrush, Kyra, Gonzalez, John, Niimi, Peter, Rozenblit, Mariya, Rozowsky, Joel, Liu, Jason, Frank, Mor, McCabe, Thomas, Higgins-Chen, Albert T., Hofstatter, Erin, Pusztai, Lajos, Beckman, Kenneth, Gerstein, Mark, Levine, Morgan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355820/
https://www.ncbi.nlm.nih.gov/pubmed/37467337
http://dx.doi.org/10.1126/sciadv.adf4163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355820/
https://www.ncbi.nlm.nih.gov/pubmed/37467337
http://dx.doi.org/10.1126/sciadv.adf4163

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