Cargando…

Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to Clostridioides difficile toxin–mediated mitochondrial damage

Clostridioides difficile damages the colonic mucosa through the action of two potent exotoxins. Factors shaping C. difficile pathogenesis are incompletely understood but are likely due to the ecological factors in the gastrointestinal ecosystem, mucosal immune responses, and environmental factors. L...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soto Ocaña, Joshua, Bayard, Nile U., Hart, Jessica L., Thomas, Audrey K., Furth, Emma E., Lacy, D. Borden, Aronoff, David M., Zackular, Joseph P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10355836/ https://www.ncbi.nlm.nih.gov/pubmed/37467340 http://dx.doi.org/10.1126/sciadv.adh5552

Ejemplares similares

Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B
por: Liu, Zheng, et al.
Publicado: (2021)

Structural Insights into the Transition of Clostridioides difficile Binary Toxin from Prepore to Pore
por: Anderson, David M., et al.
Publicado: (2019)

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection
por: Peritore-Galve, F. Christopher, et al.
Publicado: (2022)

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution
por: Janezic, Sandra, et al.
Publicado: (2020)

Reply to Noori et al., “A Complex Scenario of Nonsteroidal Anti-inflammatory Drugs Induced Prostaglandin E2 Production and Gut Microbiota Alteration in Clostridium difficile-Infected Mice”
por: Maseda, Damian, et al.
Publicado: (2020)

Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
por: Childress, Kevin O., et al.
Publicado: (2023)

An Update on Clostridioides difficile Binary Toxin
por: Martínez-Meléndez, Adrián, et al.
Publicado: (2022)

The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces
por: Glentis, Alexandros, et al.
Publicado: (2022)

Toward a structural understanding of Clostridium difficile toxins A and B
por: Pruitt, Rory N., et al.
Publicado: (2012)

Structural basis for the toxin-coregulated pilus–dependent secretion of Vibrio cholerae colonization factor
por: Oki, Hiroya, et al.
Publicado: (2022)

Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation
por: Haji-Ghassemi, Omid, et al.
Publicado: (2023)

Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci
por: Saund, Katie, et al.
Publicado: (2022)

Transcriptional census of epithelial-mesenchymal plasticity in cancer
por: Cook, David P., et al.
Publicado: (2022)

GPR15L is an epithelial inflammation-derived pruritogen
por: Tseng, Pang-Yen, et al.
Publicado: (2022)

Transcriptional control of mycobacterial DNA damage response by sigma adaptation
por: Müller, Andreas U., et al.
Publicado: (2021)

TAp63 determines the fate of oocytes against DNA damage
por: Luan, Yi, et al.
Publicado: (2022)

Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response
por: Maseda, Damian, et al.
Publicado: (2019)

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
por: Junemann, Johannes, et al.
Publicado: (2018)

Phase separation of an actin nucleator by junctional microtubules regulates epithelial function
por: Tsukita, Kazuto, et al.
Publicado: (2023)

Accelerated epithelial layer healing induced by tactile anisotropy in surface topography
por: Pramotton, Francesca Michela, et al.
Publicado: (2023)

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism
por: Chumbler, Nicole M., et al.
Publicado: (2012)

Avidity-based biosensors for ubiquitylated PCNA reveal choreography of DNA damage bypass
por: Yakoub, George, et al.
Publicado: (2023)

The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity
por: Zhang, Nan, et al.
Publicado: (2023)

EpCAM-targeting CAR-T cell immunotherapy is safe and efficacious for epithelial tumors
por: Li, Dan, et al.
Publicado: (2023)

PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle
por: Bailey, Laura J., et al.
Publicado: (2021)

Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis
por: Chandrasekaran, Ramyavardhanee, et al.
Publicado: (2016)

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection
por: López-Cárdenas, Salvador, et al.
Publicado: (2021)

Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney
por: Pace, Jesse A., et al.
Publicado: (2021)

The transcription factor Zic4 promotes tentacle formation and prevents epithelial transdifferentiation in Hydra
por: Vogg, Matthias Christian, et al.
Publicado: (2022)

Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development
por: Malin, Justin, et al.
Publicado: (2023)

Host Immune Responses to Clostridioides difficile: Toxins and Beyond
por: Nibbering, Britt, et al.
Publicado: (2021)

Structure and conformational dynamics of Clostridioides difficile toxin A
por: Chen, Baohua, et al.
Publicado: (2022)

Non-Toxin-Based Clostridioides difficile Vaccination Approaches
por: Razim, Agnieszka, et al.
Publicado: (2023)

Diversity of binary toxin positive Clostridioides difficile in Korea
por: Kim, Jieun, et al.
Publicado: (2023)

Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation
por: Oda, Yukako, et al.
Publicado: (2021)

Epigenetic controls of Sonic hedgehog guarantee fidelity of epithelial adult stem cells trajectory in regeneration
por: Yu, Fanyuan, et al.
Publicado: (2022)

In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis
por: Yavitt, F. Max, et al.
Publicado: (2023)

Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains
por: Jafari, Gholamali, et al.
Publicado: (2023)

An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
por: Hansen, Stine L., et al.
Publicado: (2023)

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage
por: Chatzidoukaki, Ourania, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uer6trlnpu0cl9mb4tubnsfgrn