Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3‐Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects

BACKGROUND: The ketone body 3‐hydroxybutyrate (3‐OHB) increases cardiac output (CO) in patients with heart failure through unknown mechanisms. 3‐OHB activates the hydroxycarboxylic acid receptor 2 (HCA(2)), which increases prostaglandins and suppresses circulating free fatty acids. We investigated w...

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Detalles Bibliográficos
Autores principales: Gopalasingam, Nigopan, Christensen, Kristian Hylleberg, Berg Hansen, Kristoffer, Nielsen, Roni, Johannsen, Mogens, Gormsen, Lars Christian, Boedtkjer, Ebbe, Nørregaard, Rikke, Møller, Niels, Wiggers, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356045/
https://www.ncbi.nlm.nih.gov/pubmed/37301762
http://dx.doi.org/10.1161/JAHA.123.029849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356045/
https://www.ncbi.nlm.nih.gov/pubmed/37301762
http://dx.doi.org/10.1161/JAHA.123.029849

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