Cargando…
Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function
BACKGROUND: Identifying new therapeutic targets for preventing the myocardial ischemia–reperfusion injury would have profound implications in cardiovascular medicine. Myocardial ischemia–reperfusion injury remains a major clinical burden in patients with coronary artery disease. METHODS AND RESULTS:...
Autores principales: | Zhabyeyev, Pavel, McLean, Brent, Bassiouni, Wesam, Valencia, Robert, Paul, Manish, Darwesh, Ahmed M., Seubert, John M., Hazra, Saugata, Oudit, Gavin Y. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356046/ https://www.ncbi.nlm.nih.gov/pubmed/37318009 http://dx.doi.org/10.1161/JAHA.122.022352 |
Ejemplares similares
-
A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3–NLRP3 Pathway
por: Darwesh, Ahmed M., et al.
Publicado: (2020) -
Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues
por: Wang, Wang, et al.
Publicado: (2013) -
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease
por: Patel, Vaibhav B., et al.
Publicado: (2018) -
PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction
por: McLean, Brent A., et al.
Publicado: (2019) -
PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
por: Zhabyeyev, Pavel, et al.
Publicado: (2019)