Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients’ samples that muscle stem cells/myoblasts exhibit signs of cellular sene...

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Detalles Bibliográficos
Autores principales: Conte, Talita C., Duran-Bishop, Gilberto, Orfi, Zakaria, Mokhtari, Inès, Deprez, Alyson, Côté, Isabelle, Molina, Thomas, Kim, Tae-Yeon, Tellier, Lydia, Roussel, Marie-Pier, Maggiorani, Damien, Benabdallah, Basma, Leclerc, Severine, Feulner, Lara, Pellerito, Ornella, Mathieu, Jean, Andelfinger, Gregor, Gagnon, Cynthia, Beauséjour, Christian, McGraw, Serge, Duchesne, Elise, Dumont, Nicolas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356779/
https://www.ncbi.nlm.nih.gov/pubmed/37468473
http://dx.doi.org/10.1038/s41467-023-39663-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356779/
https://www.ncbi.nlm.nih.gov/pubmed/37468473
http://dx.doi.org/10.1038/s41467-023-39663-3

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