Photodynamic therapy changes tumour immunogenicity and promotes immune-checkpoint blockade response, particularly when combined with micromechanical priming

Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disr...

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Detalles Bibliográficos
Autores principales: Lobo, Catarina S., Mendes, Maria Inês P., Pereira, Diogo A., Gomes-da-Silva, Lígia C., Arnaut, Luis G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356828/
https://www.ncbi.nlm.nih.gov/pubmed/37468749
http://dx.doi.org/10.1038/s41598-023-38862-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356828/
https://www.ncbi.nlm.nih.gov/pubmed/37468749
http://dx.doi.org/10.1038/s41598-023-38862-8

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