A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs

In vitro secondary pharmacology assays are an important tool for predicting clinical adverse drug reactions (ADRs) of investigational drugs. We created the Secondary Pharmacology Database (SPD) by testing 1958 drugs using 200 assays to validate target-ADR associations. Compared to public and subscri...

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Detalles Bibliográficos
Autores principales: Sutherland, Jeffrey J., Yonchev, Dimitar, Fekete, Alexander, Urban, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356841/
https://www.ncbi.nlm.nih.gov/pubmed/37468498
http://dx.doi.org/10.1038/s41467-023-40064-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356841/
https://www.ncbi.nlm.nih.gov/pubmed/37468498
http://dx.doi.org/10.1038/s41467-023-40064-9

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