Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction

The large cytosolic GTPase, dynamin-related protein 1 (Drp1), mediates both physiological and pathological mitochondrial fission. Cell stress triggers Drp1 binding to mitochondrial Fis1 and subsequently, mitochondrial fragmentation, ROS production, metabolic collapse, and cell death. Because Drp1 al...

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Detalles Bibliográficos
Autores principales: Rios, Luis, Pokhrel, Suman, Li, Sin-Jin, Heo, Gwangbeom, Haileselassie, Bereketeab, Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356917/
https://www.ncbi.nlm.nih.gov/pubmed/37468472
http://dx.doi.org/10.1038/s41467-023-40043-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356917/
https://www.ncbi.nlm.nih.gov/pubmed/37468472
http://dx.doi.org/10.1038/s41467-023-40043-0

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