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Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction
The large cytosolic GTPase, dynamin-related protein 1 (Drp1), mediates both physiological and pathological mitochondrial fission. Cell stress triggers Drp1 binding to mitochondrial Fis1 and subsequently, mitochondrial fragmentation, ROS production, metabolic collapse, and cell death. Because Drp1 al...
Autores principales: | Rios, Luis, Pokhrel, Suman, Li, Sin-Jin, Heo, Gwangbeom, Haileselassie, Bereketeab, Mochly-Rosen, Daria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356917/ https://www.ncbi.nlm.nih.gov/pubmed/37468472 http://dx.doi.org/10.1038/s41467-023-40043-0 |
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