Cargando…
TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension
This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disorders https://bit.ly/3P3H5V0
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Respiratory Society
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356963/ https://www.ncbi.nlm.nih.gov/pubmed/37290790 http://dx.doi.org/10.1183/13993003.00204-2023 |
| _version_ | 1785075391715606528 |
|---|---|
| author | Yeh, Fu-Chiang Chen, Chien-Nien Xie, Chong-Yang Baxan, Nicoleta Zhao, Lin Ashek, Ali Sabrin, Farah Lawrie, Allan Wilkins, Martin Zhao, Lan |
| author_facet | Yeh, Fu-Chiang Chen, Chien-Nien Xie, Chong-Yang Baxan, Nicoleta Zhao, Lin Ashek, Ali Sabrin, Farah Lawrie, Allan Wilkins, Martin Zhao, Lan |
| author_sort | Yeh, Fu-Chiang |
| collection | PubMed |
| description | This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disorders https://bit.ly/3P3H5V0 |
| format | Online Article Text |
| id | pubmed-10356963 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | European Respiratory Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103569632023-07-21 TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension Yeh, Fu-Chiang Chen, Chien-Nien Xie, Chong-Yang Baxan, Nicoleta Zhao, Lin Ashek, Ali Sabrin, Farah Lawrie, Allan Wilkins, Martin Zhao, Lan Eur Respir J Research Letters This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disorders https://bit.ly/3P3H5V0 European Respiratory Society 2023-07-20 /pmc/articles/PMC10356963/ /pubmed/37290790 http://dx.doi.org/10.1183/13993003.00204-2023 Text en Copyright ©The authors 2023. https://creativecommons.org/licenses/by/4.0/This version is distributed under the terms of the Creative Commons Attribution Licence 4.0. |
| spellingShingle | Research Letters Yeh, Fu-Chiang Chen, Chien-Nien Xie, Chong-Yang Baxan, Nicoleta Zhao, Lin Ashek, Ali Sabrin, Farah Lawrie, Allan Wilkins, Martin Zhao, Lan TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title | TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title_full | TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title_fullStr | TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title_full_unstemmed | TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title_short | TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| title_sort | tlr7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension |
| topic | Research Letters |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356963/ https://www.ncbi.nlm.nih.gov/pubmed/37290790 http://dx.doi.org/10.1183/13993003.00204-2023 |
| work_keys_str_mv | AT yehfuchiang tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT chenchiennien tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT xiechongyang tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT baxannicoleta tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT zhaolin tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT ashekali tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT sabrinfarah tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT lawrieallan tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT wilkinsmartin tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension AT zhaolan tlr78activationinducesautoimmunevasculopathyandcausesseverepulmonaryarterialhypertension |