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Aggregation-prone Tau impairs mitochondrial import, which affects organelle morphology and neuronal complexity

Mitochondrial protein import is essential for organellar biogenesis, and thereby for the sufficient supply of cytosolic ATP – which is particularly important for cells with high energy demands like neurons. This study explores the prospect of import machinery perturbation as a cause of neurodegenera...

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Detalles Bibliográficos
Autores principales: Needs, Hope I., Wilkinson, Kevin A., Henley, Jeremy M., Collinson, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357015/
https://www.ncbi.nlm.nih.gov/pubmed/37303235
http://dx.doi.org/10.1242/jcs.260993