Retromer Stabilization Improves Cognitive Function and Synaptic Plasticity in a Mouse Model of Down Syndrome

BACKGROUND: Retromer complex proteins are decreased in postmortem brain tissues from Down syndrome subjects and inversely correlate with the Alzheimer’s disease-like neuropathology. However, whether targeting in vivo the retromer system affects cognitive deficits and synaptic function in Down syndro...

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Detalles Bibliográficos
Autores principales: Curtis, Mary Elizabeth, Smith, Tiffany, Nenov, Miroslav, Blass, Benjamin E., Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357169/
https://www.ncbi.nlm.nih.gov/pubmed/37334603
http://dx.doi.org/10.3233/JAD-230205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357169/
https://www.ncbi.nlm.nih.gov/pubmed/37334603
http://dx.doi.org/10.3233/JAD-230205

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