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Prodromal Glutamatergic Modulation with Riluzole Impacts Glucose Homeostasis and Spatial Cognition in Alzheimer’s Disease Mice

BACKGROUND: Prior research supports a strong link between Alzheimer’s disease (AD) and metabolic dysfunction that involves a multi-directional interaction between glucose, glutamatergic homeostasis, and amyloid pathology. Elevated soluble amyloid-β (Aβ) is an early biomarker for AD-associated cognit...

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Detalles Bibliográficos
Autores principales: Findley, Caleigh A., McFadden, Samuel A., Cox, MaKayla F., Sime, Lindsey N., Peck, Mackenzie R., Quinn, Kathleen, Bartke, Andrzej, Hascup, Kevin N., Hascup, Erin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357216/
https://www.ncbi.nlm.nih.gov/pubmed/37248899
http://dx.doi.org/10.3233/JAD-221245