Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors

[Image: see text] Over 70 million people are currently at risk of developing Chagas Disease (CD) infection, with more than 8 million people already infected worldwide. Current treatments are limited and innovative therapies are required. Trypanosoma cruzi, the etiological agent of CD, is a purine au...

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Detalles Bibliográficos
Autores principales: Glockzin, Kayla, Meneely, Kathleen M., Hughes, Ryan, Maatouk, Sean W., Piña, Grace E., Suthagar, Kajitha, Clinch, Keith, Buckler, Joshua N., Lamb, Audrey L., Tyler, Peter C., Meek, Thomas D., Katzfuss, Ardala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357585/
https://www.ncbi.nlm.nih.gov/pubmed/37418678
http://dx.doi.org/10.1021/acs.biochem.3c00116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357585/
https://www.ncbi.nlm.nih.gov/pubmed/37418678
http://dx.doi.org/10.1021/acs.biochem.3c00116

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