A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely unclear. State-of-the-art mass spectrometry (MS) methods can com...

Descripción completa

Detalles Bibliográficos
Autores principales: Boeddrich, Annett, Haenig, Christian, Neuendorf, Nancy, Blanc, Eric, Ivanov, Andranik, Kirchner, Marieluise, Schleumann, Philipp, Bayraktaroğlu, Irem, Richter, Matthias, Molenda, Christine Mirjam, Sporbert, Anje, Zenkner, Martina, Schnoegl, Sigrid, Suenkel, Christin, Schneider, Luisa-Sophie, Rybak-Wolf, Agnieszka, Kochnowsky, Bianca, Byrne, Lauren M., Wild, Edward J., Nielsen, Jørgen E., Dittmar, Gunnar, Peters, Oliver, Beule, Dieter, Wanker, Erich E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357615/
https://www.ncbi.nlm.nih.gov/pubmed/37468900
http://dx.doi.org/10.1186/s13073-023-01206-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357615/
https://www.ncbi.nlm.nih.gov/pubmed/37468900
http://dx.doi.org/10.1186/s13073-023-01206-2

Ejemplares similares