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Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach
[Image: see text] A series of novel alkyl derivatives (2–5a,b) and 1H-1,2,3-triazole analogues (7a–k) of Meldrum’s acid were synthesized in a highly effective way by using “click” chemistry and screened for in vitro α-glucosidase inhibitory activity to examine their antidiabetic potential. (1)H NMR,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357758/ https://www.ncbi.nlm.nih.gov/pubmed/37483205 http://dx.doi.org/10.1021/acsomega.3c01291 |