Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach

[Image: see text] A series of novel alkyl derivatives (2–5a,b) and 1H-1,2,3-triazole analogues (7a–k) of Meldrum’s acid were synthesized in a highly effective way by using “click” chemistry and screened for in vitro α-glucosidase inhibitory activity to examine their antidiabetic potential. (1)H NMR,...

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Detalles Bibliográficos
Autores principales: Avula, Satya Kumar, Ullah, Saeed, Halim, Sobia Ahsan, Khan, Ajmal, Anwar, Muhammad U., Csuk, René, Al-Harrasi, Ahmed, Rostami, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357758/
https://www.ncbi.nlm.nih.gov/pubmed/37483205
http://dx.doi.org/10.1021/acsomega.3c01291

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