β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in Braf(V600E) -driven thyroid cancer cells
INTRODUCTION: BRAF(V600E) mutations frequently occur in papillary thyroid cancer (PTC). β-catenin, encoded by CTNNB1, is a key downstream component of the canonical Wnt signaling pathway and is often overexpressed in PTC. BRAF(V600E) -driven PTC tumors rely on Wnt/β-catenin signaling to sustain grow...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358762/ https://www.ncbi.nlm.nih.gov/pubmed/37483610 http://dx.doi.org/10.3389/fimmu.2023.1171816 |