β-catenin attenuation leads to up-regulation of activating NKG2D ligands and tumor regression in Braf(V600E) -driven thyroid cancer cells

INTRODUCTION: BRAF(V600E) mutations frequently occur in papillary thyroid cancer (PTC). β-catenin, encoded by CTNNB1, is a key downstream component of the canonical Wnt signaling pathway and is often overexpressed in PTC. BRAF(V600E) -driven PTC tumors rely on Wnt/β-catenin signaling to sustain grow...

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Detalles Bibliográficos
Autores principales: Zou, Minjing, Al-Yahya, Suhad, Al-Alwan, Monther, BinEssa, Huda A., Khabar, Khalid S. A., Almohanna, Falah, Assiri, Abdullah M., Altaweel, Abdulmohsen, Qattan, Amal, Meyer, Brian F., Alzahrani, Ali S., Shi, Yufei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358762/
https://www.ncbi.nlm.nih.gov/pubmed/37483610
http://dx.doi.org/10.3389/fimmu.2023.1171816