E protein binding at the Tcra enhancer promotes Tcra repertoire diversity

V(D)J recombination of antigen receptor loci is a highly developmentally regulated process. During T lymphocyte development, recombination of the Tcra gene occurs in CD4(+)CD8(+) double positive (DP) thymocytes and requires the Tcra enhancer (Eα). E proteins are known regulators of DP thymocyte deve...

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Detalles Bibliográficos
Autores principales: Mihai, Ariana, Roy, Sumedha, Krangel, Michael S., Zhuang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358851/
https://www.ncbi.nlm.nih.gov/pubmed/37483636
http://dx.doi.org/10.3389/fimmu.2023.1188738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358851/
https://www.ncbi.nlm.nih.gov/pubmed/37483636
http://dx.doi.org/10.3389/fimmu.2023.1188738

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