Enhancing the thermostability of Streptomyces cyaneofuscatus strain Ms1 tyrosinase by multi-factors rational design and molecular dynamics simulations

This study presents a multi-factor rational design strategy combined with molecular dynamics simulation to improve the thermostability of Streptomyces cyaneofuscatus strain Ms1 tyrosinase. Candidate mutation sites were identified using Discovery Studio and FoldX software, and the double mutant G124W...

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Detalles Bibliográficos
Autores principales: Li, Zhengtao, Zhao, Chen, Li, Duanhua, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358999/
https://www.ncbi.nlm.nih.gov/pubmed/37471348
http://dx.doi.org/10.1371/journal.pone.0288929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358999/
https://www.ncbi.nlm.nih.gov/pubmed/37471348
http://dx.doi.org/10.1371/journal.pone.0288929

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