A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

Inflammasomes are cytosolic innate immune complexes that assemble upon detection of diverse pathogen-associated cues and play a critical role in host defense and inflammatory pathogenesis. Here, we find that the human inflammasome-forming sensor CARD8 senses HIV-1 infection via site-specific cleavag...

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Detalles Bibliográficos
Autores principales: Kulsuptrakul, Jessie, Turcotte, Elizabeth A, Emerman, Michael, Mitchell, Patrick S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359095/
https://www.ncbi.nlm.nih.gov/pubmed/37417868
http://dx.doi.org/10.7554/eLife.84108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359095/
https://www.ncbi.nlm.nih.gov/pubmed/37417868
http://dx.doi.org/10.7554/eLife.84108

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