Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

The codependency of cholesterol metabolism sustains the malignant progression of glioblastoma (GBM) and effective therapeutics remain scarce. In orthotopic GBM models in male mice, we identify that codependent cholesterol metabolism in tumors induces phagocytic dysfunction in monocyte-derived tumor-...

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Detalles Bibliográficos
Autores principales: Wang, Shiqun, Yan, Wei, Kong, Lingkai, Zuo, Shuguang, Wu, Jingyi, Zhu, Chunxiao, Huang, Huaping, He, Bohao, Dong, Jie, Wei, Jiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359270/
https://www.ncbi.nlm.nih.gov/pubmed/37474548
http://dx.doi.org/10.1038/s41467-023-39683-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359270/
https://www.ncbi.nlm.nih.gov/pubmed/37474548
http://dx.doi.org/10.1038/s41467-023-39683-z

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