Enhancing bacteriophage therapeutics through in situ production and release of heterologous antimicrobial effectors

Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often limited by bacterial resistance development. Here, we engineer phages for target...

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Detalles Bibliográficos
Autores principales: Du, Jiemin, Meile, Susanne, Baggenstos, Jasmin, Jäggi, Tobias, Piffaretti, Pietro, Hunold, Laura, Matter, Cassandra I., Leitner, Lorenz, Kessler, Thomas M., Loessner, Martin J., Kilcher, Samuel, Dunne, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359290/
https://www.ncbi.nlm.nih.gov/pubmed/37474516
http://dx.doi.org/10.1038/s41467-023-39612-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359290/
https://www.ncbi.nlm.nih.gov/pubmed/37474516
http://dx.doi.org/10.1038/s41467-023-39612-0

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