Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological stud...

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Detalles Bibliográficos
Autores principales: Haake, Markus, Haack, Beatrice, Schäfer, Tina, Harter, Patrick N., Mattavelli, Greta, Eiring, Patrick, Vashist, Neha, Wedekink, Florian, Genssler, Sabrina, Fischer, Birgitt, Dahlhoff, Julia, Mokhtari, Fatemeh, Kuzkina, Anastasia, Welters, Marij J. P., Benz, Tamara M., Sorger, Lena, Thiemann, Vincent, Almanzar, Giovanni, Selle, Martina, Thein, Klara, Späth, Jacob, Gonzalez, Maria Cecilia, Reitinger, Carmen, Ipsen-Escobedo, Andrea, Wistuba-Hamprecht, Kilian, Eichler, Kristin, Filipski, Katharina, Zeiner, Pia S., Beschorner, Rudi, Goedemans, Renske, Gogolla, Falk Hagen, Hackl, Hubert, Rooswinkel, Rogier W., Thiem, Alexander, Roche, Paula Romer, Joshi, Hemant, Pühringer, Dirk, Wöckel, Achim, Diessner, Joachim E., Rüdiger, Manfred, Leo, Eugen, Cheng, Phil F., Levesque, Mitchell P., Goebeler, Matthias, Sauer, Markus, Nimmerjahn, Falk, Schuberth-Wagner, Christine, von Felten, Stefanie, Mittelbronn, Michel, Mehling, Matthias, Beilhack, Andreas, van der Burg, Sjoerd H., Riedel, Angela, Weide, Benjamin, Dummer, Reinhard, Wischhusen, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359308/
https://www.ncbi.nlm.nih.gov/pubmed/37474523
http://dx.doi.org/10.1038/s41467-023-39817-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10359308/
https://www.ncbi.nlm.nih.gov/pubmed/37474523
http://dx.doi.org/10.1038/s41467-023-39817-3

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